This case study provide insights on how two of the oldest universities in Hungary have put entrepreneurship and innovation at the core of their strategy and how they prepare and support their future entrepreneurs. The case study starts with a brief overview on the University of Debrecen followed by a short introduction on Semmelweis University and the Innovation Centre at the core of its entrepreneurial activities. Both university descriptions will be supplemented with information about the Technology Transfer Offices that define the main focus of their innovation efforts.