This publication presents the findings and recommendations of the HEInnovate review of the impact of higher education institutions (HEIs) on entrepreneurship and innovation in the Netherlands. The review assesses the strategies and practices of HEIs in the Netherlands in supporting entrepreneurship and innovation, along with the government policy context. It stresses the value creation agenda shared by the Netherlands government and its HEIs and how this agenda has created a broader understanding of knowledge exchange activities, as well as how they can be supported.