This comparative case study examines how Delft University of Technology (Netherlands), Czech Technical University (Czechia), and the University of Tartu (Estonia) are integrating artificial intelligence (AI) into teaching, learning, and research. Each institution has developed AI-specific programmes, research centres, and staff training to build competencies and foster innovation. The initiatives have led to stronger interdisciplinary collaboration, growing student interest, successful spin-offs, and evolving teaching practices. Challenges include cultural resistance, regulatory hurdles, and keeping pace with rapid AI developments. Key lessons underline the importance of leadership support, flexible structures, and peer learning to successfully integrate AI in higher education.